By Lazaros C. Triarhou
This ebook is the end result of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterized
through genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single on hand laboratory version with a protracted affliction that mimics Parkinson's illness. Structural and useful points of
intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical features of donor telephone survival, ultrastructural findings on
synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor comparable molecules, degrees of striatal amino acid receptors, and behavioural results of
unilateral and bilateral neuronal transplantations.
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Extra info for Dompaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease (Neuroscience Intelligence Unit)
Mutations affecting the central nervous system in the mouse. In: Schmitt FO, Bird SJ, Bloom FE, eds. Molecular Genetic Neuroscience. New York: Raven Press, 1982:389-400. 99. Goldowitz D, Mullen RJ. Granule cell as a site of gene action in the weaver mouse cerebellum: Evidence from heterozygous mutant chimeras. J Neurosci 1982; 2:1474-1485. 100. Goldowitz D. The weaver granuloprival phenotype is due to intrinsic action of the mutant locus in granule cells: Evidence from homozygous weaver chimeras.
Kluwer Academic Publishers cells from exiting the cell cycle by hormonal manipulation68 reduces granule cell death in both wv/wv and wv/+, thus supporting the notion that granule cell degeneration occurs after cell division has been completed. In parallel with granule cell loss, the levels of several molecules associated with granule cells in cerebellum decline postnatally. 82 Cell agglutination assays of cerebellar microcultures in the presence of plant lectins to assess defects in cell surface moieties have shown that concanavalin A and wheat germ agglutinin [specific for binding carbohydrates α-methyl-D-mannoside and (D-GlcNAc)3, respectively] induce agglutination rates 20- and 10-fold higher in wv/wv cells than in +/+ cells;83 this suggests the postnatal persistence of embryonic cell surface elements on weaver cells.
Brain Res 1990; 533:196-202. 74. Maeda N, Wada K, Yuzaki M et al. Autoradiographic visualization of a calcium channel antagonist, [125I]ω-conotoxin GVIA, binding site in the brains of normal and cerebellar mutant mice (pcd and weaver). Brain Res 1989; 489:21-30. 75. Matsui K, Furukawa S, Shibasaki H et al. Reduction of nerve growth factor level in the brain of genetically ataxic mice (weaver, reeler). Fed Eur Biochem Soc Lett 1990; 276:78-80. 76. Pickford LB, Mayer DN, Bolin LM et al. Transiently expressed, neural-specific molecule associated with premigratory granule cells in postnatal mouse cerebellum.