By Dr. William Spruill Pharm.D. FASHP FCCP, Dr. William Wade PharmD FASHP, Dr. Joseph T. DiPiro Pharm.D. FCCP, Robert A. Blouin PharmD, Jane M. Pruemer PharmD BCOP
Programmed guide offers uncomplicated pharmacokinetic innovations and methods. fabric pertains to individualization of drug dose regimens. themes comprise pharmacokinetics, half-life, removing fee, AUC, two-compartment versions, drug removal method, vancomycin, and extra. For pharmacists and practitioners. Softcover. DNLM: Pharmacokinetics-Programmed guideline.
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Extra info for Concepts In Clinical Pharmacokinetics
A. CORRECT ANSWER B, C, D. Incorrect Answer. 2 hr-1, meaning one fifth (or 20% per hour. 3-9. A, C, D. Incorrect answers B. CORRECT ANSWER. 1 hr-1, and t = 8 hours. 3-10. A, B, D. Incorrect answers C. CORRECT ANSWER. 231 hr-1, and t = 12 hours. 693/T1/2). Also, 12 hours represents four half-lives. 5 mg/L. 3-11. A, C. Incorrect answers B. CORRECT ANSWER. To find the T1/2 of 10 hours, find the interval of time necessary for the concentration to decrease from 100 to 50. 3-12. A. CORRECT ANSWER B. Incorrect answer.
10%. 3-9. 15 hr-1, predict what the plasma concentration will be 8 hours later. A. 0 mg/L B. 0 mg/L C. 5 mg/L D. 0 mg/L 3-10. For a drug that has an initial plasma concentration of 120 mg/L and a half-life of 3 hours, what would the plasma concentration be 12 hours after the initial concentration? A. 15 mg/L B. 5 C. 5 mg/L D. 60 3-11. From Figure 3-15, the approximate T1/2 is: A. 5 hours. B. 10 hours. C. 20 hours. 3-12. 564 hr-1, what is the half-life? A. 23 hours B. 81 hour C. 77 hours 3-13. To calculate drug clearance by the area method, it is necessary to first determine whether the drug best fits a one- or two-compartment model.
A. X = mY + b B. b = mY + X C. Y = mX + b D. mX + Y = b 3-2. Which of the following would be the slope of the straight line in Figure 3-12? A. ln (C0 - C1) B. t0 - t1 C. C0 - t0 D. (ln C1 - ln C0)/(t1 - t0) 3-3. Which of the following is the elimination rate constant for Figure 3-13? A. 173 B. 52 C. 231 D. 173 3-4. If two patients receive the same drug and the plots in Figure 3-14 result, which patient has the larger elimination rate constant (faster elimination)? A. Patient A B. Patient B 3-5.