Download Chronic Liver Failure: Mechanisms and Management by Fabio Marra, Maurizio Parola (auth.), Pere Ginès, Patrick S. PDF

By Fabio Marra, Maurizio Parola (auth.), Pere Ginès, Patrick S. Kamath, Vicente Arroyo (eds.)

Chronic liver failure is a widespread in scientific perform that encompasses all manifestations of sufferers with end-stage liver illnesses. power liver failure is a multiorgan syndrome that is affecting the liver, kidneys, mind, center, lungs, adrenal glands, and vascular, coagulation, and immune structures. continual Liver Failure: Mechanisms and administration covers for the 1st time all features of persistent liver failure in one ebook, from pathogenesis to present administration. every one bankruptcy is written by means of a world identified specialist of their zone and all give you the most up-to-date state of the art wisdom. This quantity is particularly designed to supply solutions to scientific inquiries to all medical professionals facing sufferers with liver ailments, not just scientific gastroenterologists and hepatologists, but additionally to internists, nephrologists, extensive care physicians, and transplant surgeons.

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Immunohistochemistry for α-SMA identifying hepatic myofibroblasts, likely derived from activation of hepatic stellate cells, in a biopsy of a cirrhotic human patient (chronic HCV infection). In all panels, myofibroblasts are identified by the brown staining in fibrogenic septae. and mobilization of retinoids are regulated by intracellular retinoidbinding proteins. Retinyl esters are a major component of the total lipid mass present in the lipid droplets of HSCs, together with triacylglycerol. Physiological conditions that require an increased utilization of retinoids at the periphery will result in the mobilization of these compounds from HSCs, which also express nuclear retinoid receptors, including retinoic acid receptors (RARs) α, β, and γ, and retinoid X receptors (RXRs) α and β, but not γ (120).

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93. Marra F, Bertolani C. Adipokines in liver diseases. Hepatology 2009;50: 957–969. 94. Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ. Mechanisms of hepatotoxicity. Toxicol Sci 2002;65:166–176. 95. Ju C, Reilly TP, Bourdi M, Radonovich MF, Brady JN, George JW, Pohl LR. Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem Res Toxicol 2002;15:1504–1513. 96. Harbrecht BG, Billiar TR. The role of nitric oxide in Kupffer cell-hepatocyte interactions.

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