By Liang-Fu Zhou, Guohua Xi, Xian-Cheng Chen, Richard F. Keep, Feng-Ping Huang, Ya Hua, Yi-Cheng Lu, Karin Muraszko
Cerebral hemorrhage is a standard and infrequently deadly subtype of stroke. whereas long ago it has got rather little cognizance in comparison to ischemic stroke, there were significant advances in our realizing of this devastating type of stroke. The papers via international specialists conceal the sector from molecular biology to medical trials.
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Kondo Y, Kanzawa T, Sawaya R, Kondo S (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5: 726–734 11. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G (2004) Deferoxamine-induced attenuation of brain edema and neurological deﬁcits in a rat model of intracerebral hemorrhage. J Neurosurg 100: 672–678 12. Siesj€o BK, Agardh CD, Bengtsson F (1989) Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1: 165–211 13. Song S, Hua Y, Keep RF, Hoff JT, Xi G (2007) A new hippocampal model for examining intracerebral hemorrhage-related neuronal death: effects of deferoxamine on hemoglobin-induced neuronal death.
8), did not lead to an improvement either. Conclusion Lipid peroxidation was reduced by 15 mg=kg of melatonin 3 h after ICH induction. These results support the previously described antioxidant effects of melatonin in multiple rat cerebral injury and in vitro neuronal studies The antioxidant effects of melatonin after ICH in rats [3, 4, 12, 14]. Although others reported improvements in neurological function after treatment with an ICH free radical trapping agent , we did not. This could be partially explained by differences in the drug delivery system; speciﬁcally, their use of a continuous, subcutaneous mini-pump, as compared to our intraperitoneal method.
Brain Res 1039: 30–36 Ogihara K, Zubkov AY, Bernanke DH, Lewis AI, Parent AD, Zhang JH (1999) Oxyhemoglobin-induced apoptosis in cultured endothelial cells. J Neurosurg 91: 459–465 Palmer C, Roberts RL, Bero C (1994) Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25: 1039–1045 Prass K, Ruscher K, Karsch M, Isaev N, Megow D, Priller J, Scharff A, Dirnagl U, Meisel A (2002) Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro.