By M. L. Thakur (auth.), Max R. Hardeman PhD, Yves Najean MD (eds.)
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Additional info for Blood cells in nuclear medicine, part I: Cell kinetics and bio-distribution
Sample text
Comparison of recovery , survival and organ uptake of 111 Inlabelled autologous platelets in 3 asplenic patients and in 6 normal subjects. Recovery Mean life span Liver/heart ratio at 20 min. (%) gamma function (days) of activity at 20 min. 02. The radioactivity of the 3 selected areas, 40 expressed as a percentage of total activity is shown in table 2. The liver activity is not higher than the precordial activity at 20 min. On day 5, the liver activity is very slightly elevated compared to the precordial activity.
N. McCOLLUM INTRODUCTION Since the introduction of lipid soluble chelates of 111 In as cell labelling agents (1) there have been a large number of reports on the in vivo and in vitro uses of Indium labelled platelets derived from man and laboratory animals. Such labelled cells have been used for the determination of deep vein thrombosis (2) renal transplant rejection and associated problems (3) and the detection of thrombogenicity in prosthetic arterial graft materials (4). Animal models have been used to evaluate prosthetic materials and medical plastics (5) drug regimes (6) and drug induced normalisation of platelet survival (7).
S. 5; 250 mOsm). 5, citrate 22 mM). yrode-albumine solution. Tyrode solution is prepared sterile and apyrogen from stock solutions. s. 100 mI. s. 100 mI. s. 100 ml. s. 100 mI. 3 and osmolarity to 295 mOsm. c) Prostacyclin (PGI 2 ). s. 36 at 4°C). 1 ml aliquots and kept at -30°C for at least 6 months. 2. Radioactive products. lllIndium oxinate (Ref. IN-15P) and 3H-5-hydroxytryptamine (Ref. TRK 223) were obtained from Amersham and 125I-albumine (Ref. SARI 125 A2 3. Platelet aggregating~gents ) from CIS, France.